Niacin's Historical Significance and Cardiovascular Risk

The text discusses the historical significance of niacin deficiency, the fortification of foods with niacin to combat pellagra, and a recent study linking high niacin levels to an increased risk of cardiovascular disease. The study found that high blood levels of a breakdown product of niacin were associated with a higher risk of heart attacks, strokes, and death, independent of traditional risk factors. This discovery could potentially lead to new avenues for treatment and prevention of cardiovascular disease.

• Pellagra, a disease caused by niacin deficiency, led to a deadly epidemic in the early 20th century.
• Fortification of foods with niacin effectively eradicated pellagra, but excessive niacin intake from processed foods is now posing a risk for cardiovascular disease.
• A recent study found a significant link between high blood levels of a niacin breakdown product and an elevated risk of major adverse cardiovascular events, independent of known risk factors.